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Superoxide Dismutase - an overview. In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. General information. Orgotein, an enzyme (CuZn superoxide dismutase) that is present in all mammalian cells, is obtained from bovine liver by several steps, including chromatography.It can be given parenterally or topically and has been used to treat conditions such as radiation cystitis [1–7 ...
Get PriceExtracellular superoxide dismutase (ECSOD) ECSOD is the major extracellular SOD of the pulmonary fluids and interstitial spaces of the lungs, which is the major organ expressing this enzyme in both rats and humans. ECSOD is abundant in blood vessels and airways. It accounts for about 70% of the total SOD in certain pulmonary and systemic blood ...
Get PriceSuperoxide Dismutase. Superoxide dismutases (SOD) are a group of enzymes that catalyze the dismutation of superoxide radicals (O2−) to molecular oxygen (O2) and hydrogen peroxide (H2O2), providing cellular defense against reactive oxygen species (24). From: Emery and Rimoin's Principles and Practice of Medical Genetics, 2013.
Get Price2021-8-7u2002·u2002Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea in human and animal. To determine the mechanism of a bovine lactoferricin-lactoferrampin (LFCA)-encoding Lactobacillus reuteri CO21 (LR-LFCA) to enhance the intestinal mucosal immunity, we used a newborn piglet intestine model to study the intestinal response to ETEC. Pigs were chosen due to the …
Get Price2017-4-26u2002·u2002Cellular superoxide dismutase (SOD), catalyzes the dismutation of O.− 2 into H 2 O 2, which is an important antioxidant defense to oxidative stress (Forman, 2016). Therefore, it is worth to investigate the effect of the HMF on the function of key regulators for redox homeostasis for a further understanding on the biomagnetic response.
Get Price2.3. Confirmation of gMnSOD and TAT–gMnSOD protein expression through Western blot analysis. A total of 100 ng of plasmid pET-22b-gMnSOD and pET-22b-TAT-gMnSOD were transformed into 100 μL of E.coli BL21 competent cells through heat shock at 42 °C for 60 s. Then, 600 μL of LB broth was added, and the cells were allowed to recover for 60 min at 37 °C with agitation and were then plated on ...
Get Price2002-6-6u2002·u2002According to the company, superoxide dismutase is a master defence enzyme and powerhouse antioxidant which occurs naturally in human cells. The production of SOD in the body decreases during the ageing process. GliSODin is derived …
Get Price2016-6-1u2002·u2002With respect to innate immunity, cytokines exert their diverse effects by initiating the inflammatory response and facilitating the migration of leukocytes from blood into infected tissues following bacterial recognition by local cell populations (Ryman et al., 2015a). The pattern of cytokine expression by cells in the body will differ ...
Get Price2014-9-29u2002·u2002Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play important roles in immunity, cell growth, and cell signaling. …
Get PriceSuperoxide Dismutase. Superoxide dismutases (SOD) are a group of enzymes that catalyze the dismutation of superoxide radicals (O2−) to molecular oxygen (O2) and hydrogen peroxide (H2O2), providing cellular defense against reactive oxygen species (24). From: Emery and Rimoin's Principles and Practice of Medical Genetics, 2013.
Get Price2014-2-15u2002·u2002Extracellular superoxide dismutase (ecSOD) binds to heparin sulfate proteoglycans on cellular surface as a unique scavenger of superoxide anions in the extracellular space . Many studies have shown that direct gene transfer of the cDNA encoding membrane-bound human ecSOD affords transient cardio-protective effect [ 3, 5 ].
Get PriceAbstract Objective To examine the influence of superoxide on the severity of collagen‐induced arthritis (CIA) in mice. Methods CIA was induced in DBA/1J mice lacking the extracellular superoxide …
Get Price2018-3-30u2002·u2002The copper-containing superoxide dismutases (SODs) represent a large family of enzymes that participate in the metabolism of reactive oxygen species by disproportionating superoxide anion radical to oxygen and hydrogen peroxide. Catalysis is driven by the redox-active copper ion, and in most cases, SODs also harbor a zinc at the active site that enhances copper …
Get Price2009-12-17u2002·u2002Ough, M. et al. Inhibition of cell growth by overexpression of manganese superoxide dismutase (MnSOD) in human pancreatic carcinoma. Free Radic. Res. 38, 1223–1233 (2004).
Get Price2021-7-28u2002·u2002fibroblasts produce superoxide during the process of wound healing, where the superoxide can quickly dismutase to hydrogen peroxide (H 2O 2) (broadly known as a cytotoxic agent) and oxygen (O 2) by constitutive and inducible superoxide dismutases (SOD). Superoxide is strong oxidants and is the main component of reactive oxygen species (ROS)
Get Price2008-7-9u2002·u2002dismutase (Cu/Zn-SOD) and also traces of Mn-superoxide dismutase (Mn-SOD) (L ANDMARK - M ANSSON and A KESSON, 2000; H ICKS. 1980), both of which were previously thoroughly characterized in some bovine cells (McC ORD and FRIDOVICH, 1969; E VANS et al.,1974; A BERNETHY, 1974). These enzymes perform
Get PriceFerulic acid inhibits LPS-induced apoptosis in bovine mammary epithelial cells by regulating the NF-κB and Nrf2 signalling pathways to restore mitochondrial dynamics and ROS generation
Get PriceThe mammary epithelial cells (MECs) of high-producing dairy cows are likely to be subject to oxidative stress (OS) due to the intensive cell metabolism. The objectives of this study were to investigate the cytoprotective effects of resveratrol against hydrogen peroxide- (H 2 O 2 -) induced OS in cultured bovine MECs (MAC-T).
Get Price2020-11-11u2002·u2002Cell viability was evaluated using the cell counting kit-8 (CCK-8) solution assay (Dojindo, Kumamoto, Japan). Briefly, H9c2 cells were seeded at a density of 1 104 cells per well in 96-well plates. After various treatments, 10 mlof CCK-8 solution was added to the cells and incubated for 2 h following the manufacturer's specifications. The cell
Get PriceAbstract Objective To examine the influence of superoxide on the severity of collagen‐induced arthritis (CIA) in mice. Methods CIA was induced in DBA/1J mice lacking the extracellular superoxide di...
Get Price2014-2-15u2002·u2002Extracellular superoxide dismutase (ecSOD) binds to heparin sulfate proteoglycans on cellular surface as a unique scavenger of superoxide anions in the extracellular space . Many studies have shown that direct gene transfer of the cDNA encoding membrane-bound human ecSOD affords transient cardio-protective effect [ 3, 5 ].
Get Price2021-7-28u2002·u2002fibroblasts produce superoxide during the process of wound healing, where the superoxide can quickly dismutase to hydrogen peroxide (H 2O 2) (broadly known as a cytotoxic agent) and oxygen (O 2) by constitutive and inducible superoxide dismutases (SOD). Superoxide is strong oxidants and is the main component of reactive oxygen species (ROS)
Get Price2009-12-17u2002·u2002Ough, M. et al. Inhibition of cell growth by overexpression of manganese superoxide dismutase (MnSOD) in human pancreatic carcinoma. Free Radic. Res. 38, 1223–1233 (2004).
Get Price2008-7-9u2002·u2002dismutase (Cu/Zn-SOD) and also traces of Mn-superoxide dismutase (Mn-SOD) (L ANDMARK - M ANSSON and A KESSON, 2000; H ICKS. 1980), both of which were previously thoroughly characterized in some bovine cells (McC ORD and FRIDOVICH, 1969; E VANS et al.,1974; A BERNETHY, 1974). These enzymes perform
Get PriceThe mammary epithelial cells (MECs) of high-producing dairy cows are likely to be subject to oxidative stress (OS) due to the intensive cell metabolism. The objectives of this study were to investigate the cytoprotective effects of resveratrol against hydrogen peroxide- (H 2 O 2 …
Get PriceFerulic acid inhibits LPS-induced apoptosis in bovine mammary epithelial cells by regulating the NF-κB and Nrf2 signalling pathways to restore mitochondrial dynamics and ROS generation
Get PriceBrucellosis is a (zoonotic) disease that can transmit to humans, usually following exposure to infected animal fluids, or their products, such as unpasteurized milk [1, 2, 3, 4].Brucellosis is closely linked to low productivity in animals, resulting in economic loss [].The lowered reproduction in affected animals is related to the poorly understood mechanism of bacterial placenta localization ...
Get Price2020-11-11u2002·u2002Cell viability was evaluated using the cell counting kit-8 (CCK-8) solution assay (Dojindo, Kumamoto, Japan). Briefly, H9c2 cells were seeded at a density of 1 104 cells per well in 96-well plates. After various treatments, 10 mlof CCK-8 solution was added to the cells and incubated for 2 h following the manufacturer's specifications. The cell
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Get Price2009-12-17u2002·u2002Ough, M. et al. Inhibition of cell growth by overexpression of manganese superoxide dismutase (MnSOD) in human pancreatic carcinoma. Free Radic. Res. 38, 1223–1233 (2004).
Get Price2014-2-15u2002·u2002Extracellular superoxide dismutase (ecSOD) binds to heparin sulfate proteoglycans on cellular surface as a unique scavenger of superoxide anions in the extracellular space . Many studies have shown that direct gene transfer of the cDNA encoding membrane-bound human ecSOD affords transient cardio-protective effect [ 3, 5 ].
Get Price2021-7-28u2002·u2002fibroblasts produce superoxide during the process of wound healing, where the superoxide can quickly dismutase to hydrogen peroxide (H 2O 2) (broadly known as a cytotoxic agent) and oxygen (O 2) by constitutive and inducible superoxide dismutases (SOD). Superoxide is strong oxidants and is the main component of reactive oxygen species (ROS)
Get Price2020-3-5u2002·u2002Nitric oxide is removed within seconds in vivo by diffusion over 100 microns through tissues to enter red blood cells and react with oxyhemoglobin. The direct toxicity of nitric oxide is modest but is greatly enhanced by reacting with superoxide to form peroxynitrite (ONOO-).
Get PriceInflammatory eye diseases remain the most common clinical problem in ophthalmology. The secondary processes associated with inflammation, such as overproduction of reactive oxygen species (ROS) and exhaustion of the endogenous antioxidant system, frequently lead to tissue degeneration, vision blurring, and even blindness. Antioxidant enzymes, such as copper–zinc …
Get PriceThe mammary epithelial cells (MECs) of high-producing dairy cows are likely to be subject to oxidative stress (OS) due to the intensive cell metabolism. The objectives of this study were to investigate the cytoprotective effects of resveratrol against hydrogen peroxide- (H 2 O 2 -) induced OS in cultured bovine MECs (MAC-T).
Get Price2021-9-6u2002·u2002Superoxide dismutase is one of the most important antioxidant enzymes that protect cells against destructive effects of superoxide anion.The aim of this study was to evaluate the association between the C47T polymorphism (rs4880) of the manganese superoxide dismutase (Mn-SOD) gene and the risk of malignant lymphoproliferative disorders (MLDs ...
Get PriceThe Wan-Nian-Qing prescription (WNQP), an herbal composite containing Ornithogalum caudatum, has been used in China for several years for cancer treatment. However, the mechanism of its pharmacological action against liver cancer is not clear. This study aimed to investigate the role of WNQP in inhibiting tumor growth in hepatocellular carcinoma model mice and determine its …
Get Price2020-11-11u2002·u2002Cell viability was evaluated using the cell counting kit-8 (CCK-8) solution assay (Dojindo, Kumamoto, Japan). Briefly, H9c2 cells were seeded at a density of 1 104 cells per well in 96-well plates. After various treatments, 10 mlof CCK-8 solution was added to the cells and incubated for 2 h following the manufacturer's specifications. The cell
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Get Price2021-7-28u2002·u2002fibroblasts produce superoxide during the process of wound healing, where the superoxide can quickly dismutase to hydrogen peroxide (H 2O 2) (broadly known as a cytotoxic agent) and oxygen (O 2) by constitutive and inducible superoxide dismutases (SOD). Superoxide is strong oxidants and is the main component of reactive oxygen species (ROS)
Get Price2020-3-5u2002·u2002Nitric oxide is removed within seconds in vivo by diffusion over 100 microns through tissues to enter red blood cells and react with oxyhemoglobin. The direct toxicity of nitric oxide is modest but is greatly enhanced by reacting with superoxide to form peroxynitrite (ONOO-).
Get PriceInflammatory eye diseases remain the most common clinical problem in ophthalmology. The secondary processes associated with inflammation, such as overproduction of reactive oxygen species (ROS) and exhaustion of the endogenous antioxidant system, frequently lead to tissue degeneration, vision blurring, and even blindness. Antioxidant enzymes, such as copper–zinc superoxide dismutase (SOD1 ...
Get PriceKusuyama et al. define a novel mechanism for placental transmission of improved metabolic health to offspring. SOD3 is identified as an exercise-induced and vitamin D-regulated placenta-derived protein that improves glucose homeostasis in offspring. SOD3 activates an AMPK/TET signaling axis resulting in epigenetic changes to metabolic genes in offspring liver.
Get Price2014-3-5u2002·u2002Abstract Significance: The mitochondrial antioxidant manganese superoxide dismutase (MnSOD) is encoded by genomic DNA and its dismutase function is fully activated in the mitochondria to detoxify free radical O2•− generated by mitochondrial respiration. Accumulating evidence shows an extensive communication between the mitochondria and cytoplasm under oxidative stress. Not only is …
Get Price2021-9-6u2002·u2002Superoxide dismutase is one of the most important antioxidant enzymes that protect cells against destructive effects of superoxide anion.The aim of this study was to evaluate the association between the C47T polymorphism (rs4880) of the manganese superoxide dismutase (Mn-SOD) gene and the risk of malignant lymphoproliferative disorders (MLDs ...
Get Price2 Institute of Health and Nutrition, Anyang, Gyeonggi 14028, Korea. 3 Department of Food and Nutrition, Daejeon University, Daejeon 34520, Korea. To whom correspondence should be addressed. tel: +82-42-280-2476, Email: [email protected] **These authors contributed equally to this article. Received March 27, 2019; Revised June 08, 2019; Accepted ...
Get Price2021-1-1u2002·u2002Bovine or equine serum (2–5%) must be added for the growth of strains such as B. abortus biovar 2. Blood agar base or Columbia agar provides excellent results. Serum–dextrose agar (SDA) or glycerol dextrose agar are other satisfactory media and help in …
Get Price2021-9-30u2002·u2002Metabolism - Clinical and Experimental. Metabolism promotes excellence in research by publishing high-quality original research papers, fast-tracking cutting-edge papers, research brief reports, mini-reviews, and other special articles related to all aspects of human metabolism. Work considered for publication in Metabolism includes studies in ...
Get PriceLi SJ, Tao Y, Yang JQ. The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase. Cancer Res, 2000; 60:3927–39. Lu SC. Regulation of glutathione synthesis. Mol Aspects Med, 2009.; 30(1–2):42–59. CrossRef. Marelli M, Conforti F, Araniti F, Statti AA.
Get PriceThe SOD1 gene encodes superoxide dismutase-1 (EC 1.15.1.1), a major cytoplasmic antioxidant enzyme that metabolizes superoxide radicals to molecular oxygen and hydrogen peroxide, thus providing a defense against oxygen toxicity (Niwa et al., 2007).Soluble cytoplasmic SOD1 is a copper- and zinc-containing enzyme; the SOD1 gene maps to chromosome 21q22 (Sherman et al., 1983).
Get PriceInflammatory eye diseases remain the most common clinical problem in ophthalmology. The secondary processes associated with inflammation, such as overproduction of reactive oxygen species (ROS) and exhaustion of the endogenous antioxidant system, frequently lead to tissue degeneration, vision blurring, and even blindness. Antioxidant enzymes, such as copper–zinc superoxide dismutase (SOD1 ...
Get Price2007-11-12u2002·u2002Infections can aggravate the course of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Mutations in the anti-oxidant enzyme Cu,Zn superoxide dismutase (EC 1.15.1.1, SOD1) are associated with familial ALS. Streptococcus pneumoniae, the most frequent respiratory pathogen, causes damage by the action of the cholesterol-binding virulence factor pneumolysin and by ...
Get PriceThe superoxide dismutase deals with superoxide radical, catalyzing the dismutation (or partitioning) of O 2-into either oxygen (O 2) or hydrogen peroxide (H 2 O 2) (Vasconcelos et al., 2007). In juvenile pacu, the evaluation of SOD revealed a greater ability to deal with the generation of superoxide species at 60 days, contrary to that observed ...
Get Price7. Fink RC, Scandalios JG. Molecular Evolution and Structure-Function Relationships of the Superoxide Dismutase Gene Families in Angiosperms and Their Relationship to Other Eukaryotic and Prokaryotic Superoxide Dismutases. Arch Biochem Biophys. 2002;399(1):19–36. doi: 10.1006/abbi.2001.2739 11883900. 8.
Get Price2020-8-19u2002·u2002Amyotrophic lateral sclerosis (ALS) is characterized by adult-onset progressive degeneration of upper and lower motor neurons. Increasing numbers of genes are found to be associated with ALS; among those, the first identified gene, SOD1 coding a Cu/Zn-superoxide dismutase protein (SOD1), has been regarded as the gold standard in the research on a pathomechanism of ALS.
Get PriceLi SJ, Tao Y, Yang JQ. The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase. Cancer Res, 2000; 60:3927–39. Lu SC. Regulation of glutathione synthesis. Mol Aspects Med, 2009.; 30(1–2):42–59. CrossRef. Marelli M, Conforti F, Araniti F, Statti AA.
Get Price2009-7-24u2002·u2002Author Summary Acne vulgaris is a chronic inflammatory disorder of the sebaceous follicles. It is the most common skin disease, affecting up to 80% of individuals at some point between the ages of 11 and 30 years. Propionibacterium acnes (P. acnes) plays a role in the development of inflammatory acne lesions, but whether it causes inflammation by itself or through indirect mechanisms is not ...
Get Price2020-8-26u2002·u2002Author summary Copper and superoxide are used by the host immune cells to limit bacterial growth during infection. We investigated the interplay between copper and superoxide in killing uropathogenic E. coli, the causative agent of urinary tract infection, by utilizing bacteriological, genetic, molecular biology, and cell culture approaches.
Get Price2014-8-1u2002·u2002In the last decade, reactive oxygen species (ROS) production has been shown to occur upon T-cell receptor (TCR) stimulation and to affect TCR-mediated signalling. However, the exact reactive species that are produced, how ROS are generated and their requirement for T-cell activation, proliferation or cytokine production remain unclear, especially in the case of primary human T cells.
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