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    2021-9-30u2002·u2002Evidence derived from animal models shows that during acute focal and global ischemia, insulin therapy reduces ischemic brain damage and may be neuroprotective. 40 It is postulated that the neuroprotective action is exerted through insulin like growth factor (IGF) type receptors. Insulin and IGF-1 were found to reduce ischemic damage when injected directly into the brain ventricles. 41 In a ...

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